A RARE FORM OF SYNCHRONOUS LUNG CANCER: MUCOEPIDERMOID CARCINOMA

TOPIC: Lung Cancer TYPE: Medical Student/Resident Case Reports INTRODUCTION: We report a unique case of lung cancer involving two different histologic variants. Mucoepidermoid carcinoma (MEC) salivary gland-type tumor and conventional adenocarcinoma CASE PRESENTATION: The patient in this study is 57-year-old male non-smoker with history hypertension, prostate deep venous thrombosis, who was incidentally found to have chest x-ray findings concerning for diaphragmatic eventration. Computed tomography (CT) the revealed linear area scarring left upper lobe 5 mm nodule lower (Figure 1, 2). Positron emission tomography-CT (PET-CT) obtained evaluate which metabolically active 2.8 x 1.5 cm opacity lobe, suspicious malignancy 3). He underwent CT guided biopsy nodule. After diagnosis, he Video-Assisted Thoracic Surgery converted into an open thoracotomy lobectomy. Microscopic examination that located peribronchial compromised components: A central MEC component, containing mucin producing cells. part negative cytokeratin 7 (CK7), thyroid transcription factor-1 (TTF-1) Napsin. surrounded by component. component presented mixed lepidic acinar patterns positive TTF-1, Napsin CK7 but P63 P40 stains. According seventh edition TNM staging tumors, clinical stage pT2aNO Stage IV. DISCUSSION: Salivary cancers are relatively rare neoplasms lung. They represent about 0.1 0.2% primary tumors detected incidentally. usually include well-defined endobronchial mass or without obstructive pneumonia atelectasis (1). genetic analysis cells standard care order select most effective therapy; however, characteristics not yet fully understood. Mutations EGFR ALK genes routinely tested identify patients could benefit from treatment target therapies. Treatment choice complete surgical excision as its controversial if pulmonary responsive chemotherapy radiotherapy; cases high-grade PMEC, adjuvant has been reserved when resection impossible. Patients unresectable disease responded EGFR-targeted therapy. CONCLUSIONS: This serves illustrate combination adenocarcinoma. Early intervention shown be favorable low-grade MEC; further investigation required need adjunct therapy future given risks developing REFERENCE #1: Li X, Zhang W, Wu et al. lung: common unusual appearances on CT. Clin Imaging. 2012;36:8–13. #2: Yousem, S.A. Hochholzer, L. (1987), Cancer, 60: 1346-1352. https://doi.org/10.1002/1097-0142(19870915)60:6<1346::AID-CNCR2820600631>3.0.CO;2-0 #3: Leonardi HK, Jung-Legg Y, Legg MA, Neptune WB. Tracheobronchial mucoepidermoid carcinoma. Clinicopathological features results treatment. J Thorac Cardiovasc Surg. 1978;76(4):431–8. DISCLOSURES: No relevant relationships Chandan Buttar, source=Web Response Debra Ferman, Sofia Lakhdar, Theo Trandafirescu,